When choosing or editing a gaming or anime PFP, focus on a strong silhouette...

https://www.slideserve.com/gierrepjfu/what-kind-of-contrast-works-best-for-profile-pictures-color-or-brightness

When choosing or editing a gaming or anime PFP, focus on a strong silhouette and good contrast to make it pop at small sizes. Crop tightly around the face and keep backgrounds simple so details don’t get lost